This is the Week 2 Wednesday game-status report for the Detroit Lions against the Buffalo Bills. Kickoff is Thursday at 8:15 p.m. ET at Highmark Stadium. Detroit lists two players out, none doubtful and one questionable.
Lions designations
Out: OL Christian Mahogany, hip, and T Blake Miller, knee. Both miss practice Monday, Tuesday and Wednesday.
Doubtful: None.
Questionable: CB D.J. Reed, foot. Reed is limited Tuesday and Wednesday.
No game designation, expected to play: DB Christian Izien, groin, and OL Juice Scruggs, knee. Izien is a full participant all three days. Scruggs is limited Monday and Tuesday, then full Wednesday.
Bills designations
Out: None.
Doubtful: None.
Questionable: S Cole Bishop, knee and groin, RB Ty Johnson, hamstring, and DL T.J. Sanders, knee and illness. Bishop is full Monday and limited Tuesday and Wednesday. Johnson is limited all three days. Sanders is limited Monday, does not practice Tuesday and is limited Wednesday.
No game designation, expected to play: ILB Terrel Bernard, calf, OLB Bradley Chubb, thumb, and DB Jordan Hancock, quad. Bernard is limited all three days. Chubb is full Monday and Tuesday, with no Wednesday participation listed. Hancock is full all three days.
Long-term updates
These Lions are on IR, PUP, or NFI. This is the progress list, not this week’s game-status report.
Brian Branch (PUP). Achilles. Latest: Opened the season on the reserve list. Campbell pointed to an early October game path. Return: first eligible in Week 5.
Kerby Joseph (PUP). Knee. Latest: Opened the season on the reserve list. Return: first eligible in Week 5.
Giovanni Manu (NFI). Knee. Latest: Opened the season on the reserve list. Campbell gave a 12-14 week window. Return: first eligible after Week 4.
Cade Mays (IR). Wrist. Latest: Opened the season on the reserve list. Return: first eligible in Week 5.
Damone Clark (IR). Undisclosed. Latest: Placed on season-ending IR. Return: season-ending.
Isiah Pacheco (IR). Back. Latest: Moved to IR on Sept. 1. Return: first eligible in Week 13.
Kendrick Law (IR). ACL. Latest: Torn ACL in OTAs. Return: will miss the rest of his debut season.
Payton Turner (IR). Back. Latest: Placed on season-ending IR. Return: season-ending.
As of September 16, 2026.
